We use a great many prefixes and suffixes all the time. In fact, I'm astonished how many affixes exist. We have over fifty of Latin origin. We have almost as many from the Greek. Over a dozen come from Anglo-Saxon origin and even a few from other languages, including Arabic.
The problem is that each affix has its limitations and shades of meaning. UN, DIS, and NON, for example, are negative prefixes. We can say unhappy but we cannot say dishappy or nonhappy. We can say unlike and dislike but not nonlike.
We can describe an organization as a nonprofit business, but we can’t call it a disprofit business, and if we call it unprofitable, we have changed the meaning of the sentence.
Some words are popular simply because of their prefixes. I can be disgruntled or disgusted but not gruntled or gusted. I can’t be nongruntled or even ungusted, either.
The problem for students learning English is that the subtle differences between affixes are very hard for a teacher to explain. So it is a matter, therefore, of listening and reading and thinking carefully before using a prefix or a suffix that you are not sure about.